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White Powder Etizolam For Lab Search Powders 99.9% Purity Pharma Intermediates Etizolam
Product Details
| Place of Origin: | China |
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| Brand Name: | |
| Certification: | ISO，CE |
| Model Number: |
Payment Terms
| Min.Order Quantity: | 5 Grams |
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| Price: | USD $10 - $100 / Gram |
| Payment Terms: | D/A,T/T |
Product Description
Introduction
Name:Etizolam
Accession Number:DB09166
Type:Small Molecule
Groups:Experimental
Description
Etizolam is a thienodiazepine which is chemically related to benzodiazepine (BDZ) drug class; it differs from BDZs in having a benzene ring replaced with a thiophene ring. It is an agonist at GABA-A receptors and possesses amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties.
Indication
Indicated for the treatment of generalized anxiety disorder with depression, panic disorder and insomnia.
Pharmacodynamics
Etizolam is a CNS depressant with anxiolytic, anticonvulsant, sedative-hypnotic and muscle relaxant effects. It acts on the benzodiazepine site of the GABA-A receptor as an agonist to increase inhibitory GABAergic transmission throughout the central nervous system. Studies indicate that etizolam mediates its pharmacological actions with 6 to 10 times more potency than that of diazepam. Clinical human studies performed in Italy showed clinical effectiveness of etizolam in relieving symptoms in patients with generalized anxiety disorders with depressive symptoms 2,3,4. Etizolam also mediates imipramine-like neuropharmacological and behavioral effects, as well as minor effects on cognitive functioning. It is shown to substitute the actions of a short-acting barbiturate, pentobarbitol, in a drug discrimination study 8. Etizolam is an antagonist at platelet-activating-factor (PAF) receptor and attenuates the recurrence of chronic subdural hematoma after neurosurgery in clinical studies 9. It is shown to inhibit PAF-induced bronchoconstriction and hypotension